Whole gamma imager

News

Introduction

Positron emission tomography (PET) plays important roles in cancer diagnosis, neuroimaging and molecular imaging research. The National Institute of Radiological Sciences, QST (NIRS) has been focusing on PET research since 1979 when NIRS developed the first PET scanner in Japan. Now NIRS is recognized as one of the world’s leading institutions in the field of molecular imaging research.

Regarding instrumentations, potential points remain for which big improvements could be made, including spatial resolution, sensitivity and manufacturing costs. Therefore, research on next generation PET technologies remains a hot topic worldwide.

A small prototype of the world's first open-type PET "OpenPET".

Highlight

  • Recognized as a Person of Collaboration Merits by the Minister of Health, Labour and Welfare, for the realization of a depth-of-interaction (DOI) detector
    Award ceremony: Recognized as a Person of Collaboration Merits by the Minister of Health, Labour and Welfare, for the realization of a depth-of-interaction (DOI) detector
  • Awarded the Science and Technology Prize by the Minister of Education, Culture, Sports, Science and Technology, for research on OpenPET
    Award ceremony: Awarded the Science and Technology Prize by the Minister of Education, Culture, Sports, Science and Technology, for research on OpenPET
  • First prototyping of the novel concept “whole gamma imaging”
    The first prototype system of whole gamma imaging (WGI)

Imaging Physics Group (IPG) succeeded in developing a novel 4-layered DOI detector, which is a key technology to get any significant improvement in sensitivity while maintaining high spatial resolution. IPT expanded PET application fields by making full use of DOI detectors. IPT invented the world’s first, open-type PET geometry "OpenPET", which is expected to lead to PET imaging during treatment. In addition to continuing work for on-going projects (OpenPET, helmet-type PET and add-on PET for MRI), IPT has started a new development project for a whole gamma imager (WGI), which is a new concept to combine PET and Compton imaging. Both DOI and OpenPET are long-term research projects which were started in 2000 and 2007, respectively. These awards, which celebrate the fruits of our labor, remind us to plant new seeds for the next generation research.

Project

Over view

PET innovation to be made by original ideas and technologies

The first midterm plan of NIRS (2001-2005)

IPT succeeded in developing a novel 4-layered DOI detector, which is a key technology to get any significant improvement in sensitivity while maintaining high spatial resolution. This DOI detector is the base for Shimadzu’s new line of positron emission mammography products.

The second midterm plan of NIRS (2006-2010)

IPT expanded PET application fields by making full use of DOI detectors. IPT invented the world’s first, open-type PET geometry OpenPET, which is expected to lead to PET imaging during treatment. The DOI detector itself evolved through application of recently developed semiconductor photodetectors, i.e., silicon photomultipliers (SiPMs). We developed a SiPM-based DOI detector X’tal cube to achieve the theoretical limitation of PET imaging resolution.

The third midterm plan of NIRS (2011-2015)

IPT made big progress with these technologies. In the OpenPET project, which received the German Innovation Award in 2012, IPT finally developed a full-scale OpenPET prototype. In addition, the flexible detector system of the OpenPET prototype enabled realization of an innovative brain scanner; this is the helmet-chin PET, which is now being commercialized in collaboration with ATOX Co., Ltd. On the other hand, technologies developed for the X’tal cube enabled a new idea of add-on PET, which can be applied to any existing MR systems in theory.

Since April 2016

NIRS has reorganized as part of the new organization, the National Institutes for Quantum and Radiological Science and Technology (QST). In addition to continuing work for these three on-going projects (OpenPET, helmet-chin PET and add-on PET), IPT has started a new development project for a whole gamma imager (WGI), which is a new concept to combine PET and Compton imaging.

  • OpenPET

    OpenPETプロジェクト

    OpenPET is our original idea to realize the world’s first open-type 3D PET scanner for PET-image guided particle therapy such as in situ dose verification and direct tumor tracking. The principal of dose verification for particle therapy is based on the measurement of positron emitters which are produced through fragmentation reactions caused by proton or 12C ion irradiation. Even with a full-ring geometry, the OpenPET has an open gap through which the treatment beam passes. In 2016, IPT showed that the difference between a PET peak position and a dose peak position could be smaller than 1 mm with the newly established 15O beam irradiation.

    In 2017, IPT continued its international collaboration. Outstanding HIMAC experiments which made full use of the potential of the OpenPET system were done. A PET-dose conversion method not only for RI beams but also for stable (12C etc.) beams was studied in collaboration with Ludwig-Maximilians-Universität München. Validation of Monte Carlo codes was investigated in collaboration with Australian Nuclear Science and Technology Organisation (ANSTO) / University of Wollongong. These results were presented at IEEE MIC 2017 as oral presentations, which were demonstrating the high quality and impact of these works.

    Brain dedicated helmet-type PET

    Brain dedicated helmet-type PET project

    Life extension is now causing another issue of rising numbers of dementia cases. To satisfy the potential demand for brain imaging, prototypes of brain PET scanners have been developed. However, all previous prototypes were based on a cylindrical geometry, which is not the most efficient for brain imaging. Making the detector ring as small as possible is essential in PET, because sensitivity can be increased with a limited number of detectors. Therefore, IPT developed the world’s first helmet-chin PET, in which DOI detectors are arranged to form a hemisphere, for compact, high-sensitivity, high-resolution, and low-cost brain PET imaging.

    In 2017, progressing towards a more patient-friendly system, we moved the chin detector unit to the back of the neck position. This change was based on our simulation, which showed that the effect of additional detectors depends on the number of detectors and does not depend significantly on their position. In practice, a 7% improvement in sensitivity was obtained because the safety margin, which was required for the chin-detectors, could be removed for the neck detectors.

    Add-on PET for MRI

    Add-on PET (PET/MRI) project

    One of the major innovations made in recent years is the combined PET/MRI, but utilization of DOI detectors has not been studied well. DOI measurements are essential for PET in order to exploit the improved spatial resolution and sensitivity as well as reduced production costs. Therefore, we proposed an add-on PET, which is a RF coil combined with DOI-PET detectors.

    In order to make the PET detector ring as small as possible while placing electronic parts such as photodetectors and front-end circuits outside the RF coil, PET detector modules were placed between spokes of the birdcage RF coil. For each detector module, electronic parts were covered with a shielding box with a hole in front of the photodetectors, and scintillators were stuck out of the shielding box to allow their placement inside the birdcage coil. In theory, the proposed birdcage coil integrated with PET detectors can be applied to any existing MRI.

    Following the development of a head-sized prototype in 2016, an oval detector arrangement was investigated, in particular we focused on the RF transmission performance, for the potential extension to whole-body PET/MRI imaging.

    Whole Gamma Imaging (WGI)

    WGI prototype

    PET is recognized as a successful imaging method, but in order to meet emerging demands such as in-situ single-level cell tracking, we need to break through an inherent limitation in the principle of PET itself. Therefore, in collaboration with Prof. Katia Parodi at Ludwig-Maximilians-Universität München and others, with support by the NIRS International Open Laboratory program and the QST President Grant, IPT started realization of the new concept of whole gamma imaging (WGI) in 2016.

    WGI is a concept utilizing all detectable gamma rays for imaging by combining PET and Compton imaging. An additional detector ring, which is used as the scatterer, is inserted in a conventional PET ring so that single gamma rays can be detected by the Compton imaging method. As a wide range of radioisotopes can be visualized, WGI is expected to enable imaging of the targeted radioisotope therapy. In addition, triple gamma emitters such as 44Sc, that emits a pair of 511 keV photons and a 1157 keV gamma ray almost at the same time, are selected as an imaging target. In theory, localization from a single decay is possible by identifying the intersection point between a coincidence line and a Compton cone.

    In 2017, following the simulation we accomplished in 2016, we succeeded in prototyping the first WGI system and showed a proof-of-concept of WGI, by visualizing a 44Sc source generated by the Department of Radiopharmaceuticals Development at NIRS. We showed the localization accuracy of the 12.7mm FWHM which was obtained as the intersection point between a coincidence line and a Compton cone. Further improvement will be possible by optimizing the detectors.

Member

Taiga Yamaya

Imaging Physics Group, Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science, QST
Group Leader

Eiji Yoshida

Imaging Physics Group, Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science, QST
Principal Researcher

Miwako Takahashi

Imaging Physics Group, Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science, QST
Principal Researcher

Naoko Inadama

Imaging Physics Group, Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science, QST
Principal Resesarcher

Hideaki Tashima

Imaging Physics Group, Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science, QST
Principal Researcher

Fumihiko Nishikido

Imaging Physics Group, Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science, QST
Senior Researcher

Mohammadi Akram

Imaging Physics Group, Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science, QST
Senior Researcher

Md Shahadat Hossain Akram

Imaging Physics Group, Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science, QST
Senior Researcher

Chie Toramatsu

Imaging Physics Group, Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science, QST
Senior Researcher

Sodai Takyu

Imaging Physics Group, Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science, QST
Researcher

Go Akamatsu

Imaging Physics Group, Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science, QST
Researcher

Kang Han Gyu

Imaging Physics Group, Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science, QST
Resaercher

Yuma Iwao

Imaging Physics Group, Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science, QST
Researcher

Hidekatsu Wakizaka

Imaging Physics Group, Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science, QST
Senior Technical Staff

Fujino Obata

Imaging Physics Group, Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science, QST
Technical Staff

Takumi Nishina

Imaging Physics Group, Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science, QST
QST Research Assistant

Suga Lab Chiba University

Madoka Ohno

Imaging Physics Group, Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science, QST
Secretary

Yu Saito

Imaging Physics Group, Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science, QST
Secretary

Masumi Tanaka

Imaging Physics Group, Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science, QST

Ryotaro Ohashi

Imaging Physics Group, Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science, QST
Trainee

Yamaya Lab Chiba University

Achievement

# Peer-reviewed articles Year
Akram Mohammadi, Naoko Inadama, Fumihiko Nishikido, Taiga Yamaya, "Development of dual-ended depth-of-interaction detectors using laser-induced crystals for small animal PET systems," Phys. Med. Biol. 66, 175029, 2021. 2021
Akram Mohammadi, Naoko Inadama, Fumihiko Nishikido, Sakai Toshiaki, Taiga Yamaya, "Optimization of the surface area of laser-induced layers for PET detectors with depth-of-interaction," Nuclear Inst. and Methods in Physics Research, A 1007, 165425, 2021. 2021
Han Gyu Kang, Fumihiko Nishikido, Taiga Yamaya, "A staggered 3-layer DOI PET detector using BaSO4 reflector for enhanced crystal identification and inter-crystal scattering event discrimination capability," Biomed. Phys. Eng. Express, 7, 035018, 2021. 2021
Go Akamatsu, Hideaki Tashima, Sodai Takyu, Han Gyu Kang, Yuma Iwao, Miwako Takahashi, Eiji Yoshida, Taiga Yamaya, "Design consideration of compact cardiac TOF-PET systems: a simulation study," Phys. Med. Biol. 66 074002, 2021 2021
Eiji Yoshida, Go Akamatsu, Hideaki Tashima, Kei Kamada, Akira Yoshikawa, Taiga Yamaya, "First imaging demonstration of a crosshair light-sharing PET detector," Phys. Med. Biol. 66, 065013, 2021 2021
Sodai Takyu, Fumihiko Nishikido, Eiji Yoshida, Munetaka Nitta, Kei Kamada, Akira Yoshikawa, Taiga Yamaya, "GAGG–MPPC detector with optimized light guide thickness for combined Compton-PET applications," Nuclear Instruments and Methods in Physics Research A: Accelerators, Spectrometers, Detectors and Associated Equipment, Volume 990, 164998, 2021, 2021
Go Akamatsu, Hideaki Tashima, Eiji Yoshida, Hidekatsu Wakizaka, Yuma Iwao, Takamasa Maeda, Miwako Takahashi, Taiga Yamaya, "Modified NEMA NU-2 performance evaluation methods for a brain-dedicated PET system with a hemispherical detector arrangement," Biomed. Phys. Eng. Express, 6, 015012, 2020. 2020
Sodai Takyu, Abdella M Ahmed, Eiji Yoshida, Hideaki Tashima, Masaaki Kumagai, Taichi Yamashita, Taiga Yamaya, "Design study of a brain-dedicated time-of-flight PET system with a hemispherical detector arrangement," Phys. Med. Biol., 65, 035012, 2020. 2020
Yukie Yoshii, Hideaki Tashima, Yuma Iwao, Eiji Yoshida, Hidekatsu Wakizaka, Go Akamatsu, Taiga Yamaya, Hiroki Matsumoto, Mitsuyoshi Yoshimoto, Chika Igarashi, Fukiko Hihara, Tomoko Tachibana, Ming-Rong Zhang, Kotaro Nagatsu, Aya Sugyo, Atsushi B Tsuji, Tatsuya Higashi, "Immuno-OpenPET: a novel approach for early diagnosis and image-guided surgery for small resectable pancreatic cancer," Scientific reports, 10(1), 4143, 2020, DOI:10.1038/s41598-020-61056-5 2020
Eiji Yoshida, Fujino Obata, Kei Kamada, Taiga Yamaya, "Development of single-ended readout DOI detector with quadrisected crystals," IEEE Transactions on Radiation and Plasma Medical Sciences, 4(5), 563-569, DOI:10.1109/TRPMS.2020.2990788 2020
Andrew Chacon, Benjamin James, Thuy Linh Tran, Susanna Guatelli, Lachlan Chartier, Dale Prokopvich, Daniel R. Franklin, Akram Mohammadi, Fumihiko Nishikido, Yuma Iwao, Go Akamatsu, Sodai Takyu, Hideaki Tashima, Taiga Yamaya, Katia Parodi, Anatoly Rosenfeld, Mitra Safavi‐Naeini, "Experimental investigation of the characteristics of radioactive beams for heavy ion therapy," Medical Physics, 47(7), 3123-3132, 2020, DOI:10.1002/mp.14177 2020
Eiji Yoshida, Hideaki Tashima, Go Akamatsu, Yuma Iwao, Miwako Takahashi, Taichi Yamashita, Taiga Yamaya, “245 ps-TOF brain-dedicated PET prototype with a hemispherical detector arrangement,” Phys. Med. Biol., 65, 145008, 2020. 2020
Eiji Yoshida, Hideaki Tashima, Kotaro Nagatsu, Atsushi Tsuji, Kei Kamada, Katia Parodi, Taiga Yamaya, "Whole gamma imaging: a new concept of PET combined with Compton," Physics in Medicine and Biology, 65(12), 125013, DOI:10.1088/1361-6560/ab8e89 2020
Chie Toramatsu, Akram Mohammadi, Hidekatsu Wakizaka, Chie Seki, Fumihiko Nishikido, Shinji Sato, Miwako Takahashi, Kumiko Karasawa, Yoshiyuki Hirano, Taiga Yamaya, "Biological washout modelling for in-beam PET: rabbit brain," Physics in Medicine and Biology, 65(10), 105011, 2020, DOI:10.1088/1361-6560/ab8532 2020
Akram Mohammadi, Hideaki Tashima, Yuma Iwao, Sodai Takyu, Go Akamatsu, Han Gyu Kang, Fumihiko Nishikido, Eiji Yoshida, Andrew Chacon, Mitra Safavi naeini, Katia Parodi, Taiga Yamaya, "Influence of momentum acceptance on range monitoring of 11C and 15O ion beams using in-beam PET," Physics in Medicine and Biology, 65(12), 125006, 2020, DOI:10.1088/1361-6560/ab8059 2020
Kengo Shibuya, Haruo Saito, Fumihiko Nishikido, Miwako Takahashi, Taiga Yamaya, "Oxygen sensing ability of positronium atom for tumor hypoxia imaging," Commun. Phys. 3, 173 2020
Han Gyu Kang, Taiga Yamaya, Young Been Han, Seong Hyun Song, Guen Bae Ko, Jae Sung Lee, Seong Jong Hong, "Crystal surface and reflector optimization for the SiPM-based dual-ended readout TOF-DOI PET detector," Biomed. Phys. Eng. Express 6, 065028 2020
Harley Rutherford, Andrew Chacon, Akram Mohammadi, Sodai Takyu, Hideaki Tashima, Eiji Yoshida, Fumihiko Nishikido, Theresa Hofmann, Marco Pinto, Daniel Robert Franklin, Taiga Yamaya, Katia Parodi, Anatoly B Rosenfeld, Susanna Guatelli, Mitra Safavi-Naeini, "Dose quantification in carbon ion therapy using in-beam positron emission tomography," Phys. Med. Biol. 65 235052 2020
Abdella M Ahmed, Andrew Chacon, Harley Rutherford, Go Akamatsu, Akram Mohammadi, Fumihiko Nishikido, Hideaki Tashima, Eiji Yoshida, Taiga Yamaya, Daniel Robert Franklin, Anatoly B Rosenfeld, Susanna Guatelli, Mitra Safavi-Naeini, "A validated Geant4 model of a hole-body PET scanner with four-layer DOI detectors," Phys. Med. Biol. 65 235051 2020
Hideaki Tashima, Eiji Yoshida, Hidekatsu Wakizaka, Miwako Takahashi, Kotaro Nagatsu, Atsushi Tsuji, Kei Kamada, Katia Parodi, Taiga Yamaya, "3D Compton image reconstruction method for whole gamma imaging," Phys. Med. Biol., 65, 225038, 2020. 2020
Han Gyu Kang, Seiichi Yamamoto, Sodai Takyu, Fumihiko Nishikido, Akram Mohammadi, Go Akamatsu, Shinji Sato, Taiga Yamaya, "Energy spread estimation of radioactive oxygen ion beams using optical imaging," Phys. Med. Biol. 65, 235002, 2020. 2020
Eiji Yoshida, Fujino Obata, Kei Kamada, Taiga Yamaya, "A crosshair light sharing PET detector with DOI and TOF capabilities using four-to-one coupling and single-ended readout," IEEE Transactions on Radiation and Plasma Medical Science, 10.1109/TRPMS.2020.3032466, 2020. (online first) 2020
Go Akamatsu, Sodai Takyu, Eiji Yoshida, Yuma Iwao, Hideaki Tashima, Fumihiko Nishikido, Taiga Yamaya, "Evaluation of a Hamamatsu TOF-PET Detector Module with 3.2 mm Pitch LFS Scintillators and a 256-channel SiPM Array," IEEE Transactions on Radiation and Plasma Medical Sciences, 10.1109/TRPMS.2020.3035876, 2020. (online first) 2020
Hideaki Tashima, Eiji Yoshida, Yuma Iwao, Hidekatsu Wakizaka, Akram Mohammadi, Munetaka Nitta, Atsushi Kitagawa, Taku Inaniwa, Fumihiko Nishikido, Atsushi Tsuji, Yuji Nagai, Chie Seki, Takafumi Minamimoto, Yasuhisa Fujibayashi, Taiga Yamaya, "Development of a multi-use human-scale single-ring OpenPET system," IEEE Transactions on Radiation and Plasma Medical Sciences, 10.1109/TRPMS.2020.3037055, 2020. (online first) 2020
G. Akamatsu, H. Tashima, Y. Iwao, H. Wakizaka, T. Maeda, E. Yoshida, T. Yamaya, "A 3-dimensional hemispherical brain phantom for compact dedicated brain PET scanners," Biomed. Phys. Eng. Express, 5, 025013, 2019. 2019
T. Hofmann, M. Pinto, A. Mohammadi, M. Nitta, F. Nishikido, Y. Iwao, H. Tashima, E. Yoshida, A. Chacon, M. SafaviNaeini, A. Rosenfeld, T. Yamaya, K. Parodi, “Dose reconstruction from PET images in carbon ion therapy: a deconvolution approach,” Phys. Med. Biol., 64, 025011, 2019. 2019
Naoko Inadama, Hideo Murayama, Fumihiko Nishikido, Junichi Ohi, Taiga Yamaya, "Improvement of a PET detector performance by setting reflectors in parallel with PMT face," IEEE Trans. Nucl. Sci., 66, pp. 497-505, 2019. 2019
Akram Mohammadi, Sodai Takyu, Fumihiko Nishikido, Eiji Yoshida, Keiji Shimizu, Toshiaki Sakai, Taiga Yamaya, "Development of a dual-end detector with TOF and DOI capabilities using crystal bars segmented by subsurface laser engraving," Nuclear Inst. and Methods in Physics Research, A 931, pp. 236–241, 2019. 2019
Andrew Chacon, Mitra Safavi-Naeini, David Bolst, Susanna Guatelli, Daniel R. Franklin, Yuma Iwao, Go Akamatsu Hideaki Tashima, Eiji Yoshida, Fumihiko Nishikido, Atsushi Kitagawa, Akram Mohammadi, Marie-Claude Gregoire, Taiga Yamaya, Anatoly B. Rosenfeld, "Monte Carlo investigation of the characteristics of radioactive beams for heavy ion therapy," Scientific Reports, 9, 6537, 2019. https://www.nature.com/articles/s41598-019-43073-1 2019
Go Akamatsu, Hideaki Tashima, Yuma Iwao, Hidekatsu Wakizaka, Takamasa Maeda, Akram Mohammadi, Sodai Takyu, Munetaka Nitta, Fumihiko Nishikido, Harley Rutherford, Andrew Chacon, Mitra Safavi-Naeini, Eiji Yoshida, Taiga Yamaya, "Performance evaluation of a whole-body prototype PET scanner with four-layer DOI detectors," Phys. Med. Biol., 64, 095014, 2019. 2019
Eiji Yoshida, Genki Hirumi, Hideaki Tashima, Sodai Takyu, Fumihiko Nishikido, Taiga Yamaya, "Four-layered DOI-PET detector with quadrisected top layer crystals," Nuclear Inst. and Methods in Physics Research, A 933, pp. 1–7, 2019. 2019
Han Gyu Kang, Seiichi Yamamoto, Sodai Takyu, Fumihiko Nishikido, Akram Mohammadi, Ryo Horita , Shinji Sato, Taiga Yamaya, "Optical imaging for the characterization of radioactive carbon and oxygen ion beams," Phys. Med. Biol. 64, 115009, 2019. (captured by physicsworld https://physicsworld.com/a/optical-imaging-characterizes-radioactive-ionbeams/) 2019
Yuma Iwao, Hideaki Tashima, Eiji Yoshida, Fumihiko Nishikido, Takahiro Ida, Taiga Yamaya, "Seated versus supine: consideration of the optimum measurement posture for brain-dedicated PET," Phys. Med. Biol., 64, 125003, 2019. 2019
Akram Mohammadi , Hideaki Tashima, Yuma Iwao, Sodai Takyu, Go Akamatsu, Fumihiko Nishikido, Eiji Yoshida, Atsushi Kitagawa, Katia Parodi, Taiga Yamaya, “Range verification of radioactive ion beams of 11C and 15O using inbeam PET imaging,” Phys. Med. Biol., 64, 145014, 2019. 2019
Andrew Chacon, Susanna Guatelli, Harley Rutherford, David Bolst, Akram Mohammadi, Abdella Ahmed, Munetaka Nitta, Fumihiko Nishikido, Yuma Iwao, Hideaki Tashima, Eiji Yoshida, Go Akamatsu, Sodai Takyu Atsushi Kitagawa, Theresa Hofmann, Marco Pinto, Daniel R Franklin, Katia Parodi, Taiga Yamaya, Anatoly Rosenfeld, Mitra Safavi-Naeini, "Comparative study of alternative Geant4 hadronic ion inelastic physics models for prediction of positron-emitting radionuclide production in carbon and oxygen ion therapy," Phys. Med. Biol., vol. 64, 155014, 2019. 2019
Keisuke Kurita, Yuta Miyoshi, Yuto Nagao, Mitsutaka Yamaguchi, Nobuo Suzui, Yong-Gen Yin, Satomi Ishii, Naoki Kawachi, Kota Hidaka, Eiji Yoshida, Sodai Takyu, Hideaki Tashima, Taiga Yamaya, “Fruit PET: 3-D imaging of carbon distribution in fruit using OpenPET,” Nuclear Inst. and Methods in Physics Research, A, on-line first, 2019. 2019
Md Shahadat Hossain Akram, Takayuki Obata, Taiga Yamaya, “Microstrip Transmission Line RF Coil for a PET/MRI Insert," Magnetic Resonance in Medical Sciences, mp.2019-0137, 2019. 2019
Hideaki Tashima, Eiji Yoshida, Yuma Iwao, Hidekatsu Wakizaka, Takamasa Maeda, Chie Seki, Yasuyuki Kimura, Yuhei Takado, Makoto Higuchi, Tetsuya Suhara, Taichi Yamashita and Taiga Yamaya, “First prototyping of a dedicated PET system with the hemisphere detector arrangement,” Phys. Med. Biol., vol. 64, no. 6, p. 065004, Jan. 2019. 2019
Akram Mohammadi, Eiji Yoshida, Fumihiko Nishikido, Munetaka Nitta, Keiji Shimizu, Toshiaki Sakai, Taiga Yamaya, “Development of a dual-ended readout detector with segmented crystal bars made using a subsurface laser engraving technique,” Physics in Medicine and Biology, Volume 63, Number 2, 025019, 2018. 2018
Chie Toramatsu, Eiji Yoshida, Hidekazu Wakizaka, Akram Mohammadi, Yoko Ikoma, Hideaki Tashima, Fumihiko Nishikido, Atsushi Kitagawa, Kumiko Karasawa, Yoshiyuki Hirano, Taiga Yamaya, “Washout effect in rabbit brain: in-beam PET measurements using 10C, 11C and 15O ion beams” Biomed. Phys. Eng. Express, 4, 035001, 2018. (Appeared in MedicalPhysicsWeb: http://medicalphysicsweb.org/cws/article/research/71337) 2018
Yukie Yoshii, Mitsuyoshi Yoshimoto, Hiroki Matsumoto, Hideaki Tashima, Yuma Iwao, Hiroyuki Takuwa, Eiji Yoshida, Hidekatsu Wakizaka, Taiga Yamaya, Ming-Rong Zhang, Aya Sugyo, Sayaka Hanadate, Atsushi B. Tsuji, Tatsuya Higashi, "Integrated treatment using intraperitoneal radioimmunotherapy and positron emission tomography-guided surgery with 64Culabeled cetuximab to treat early- and late-phase peritoneal dissemination in human gastrointestinal cancer xenografts," Oncotarget, Vol. 9, No. 48, pp. 28935-28950, 2018. 2018
Md Shahadat Hossain Akram, Craig S. Levin, Takayuki Obata, Genki Hirumi, Taiga Yamaya, "Geometry optimization of electrically floating PET inserts for improved RF penetration for a 3 T MRI system," Med. Phys., 45 (10), pp. 4627-4641, 2018. 2018
R. S. Augusto, A. Mohammadi, H. Tashima, E. Yoshida, T. Yamaya, A. Ferrari, K. Parodi, "Experimental validation of the FLUKA Monte Carlo code for dose and β+–emitter predictions of radioactive ion beams," Phys. Med. Biol., 63, 215014, 2018. 2018
Munetaka Nitta , Naoko Inadama , Fumihiko Nishikido, Eiji Yoshida , Hideaki Tashima, Hideyuki Kawai, Taiga Yamaya, "Development of the X'tal cube PET detector with segments of (0.77mm)3" IEEE Transactions on Radiation and Plasma Medical Sciences, Vol. 2, No. 6, pp. 564-573, 2018. 2018
Yuji Tsutsui, Hiromitsu Daisaki, Go Akamatsu, Takuro Umeda, Matsuyoshi Ogawa, Hironori Kajiwara, Shigeto Kawase, Minoru Sakurai, Hiroyuki Nishida, Keiichi Magota, Kazuaki Mori, Masayuki Sasaki, J-Hart study group, “Multicentre analysis of PET SUV using vendor-neutral software: the Japanese Harmonization Technology (J-Hart) study,” EJNMMI Research (2018) 8:83. 2018
Abdella M. Ahmed, Hideaki Tashima, Taiga Yamaya, "Investigation of spatial resolution improvement by use of a mouth insert detector in the helmet PET scanner," Radiol. Phys. Technol. Vol. 11, No. 1, pp. 7-12 2018
Akram Mohammadi, Eiji Yoshida, Hideaki Tashima, Fumihiko Nishikido, Taku Inaniwa, Atsushi Kitagawa, Taiga Yamaya, "Production of an 15O beam using a stable oxygen ion beam for in-beam PET imaging," Nuclear Instruments and Methods in Physics Research A 849, pp. 76–82 2017
Abdella M. Ahmed, Hideaki Tashima, Eiji Yoshida, Taiga Yamaya, " Investigation of the optimal detector arrangement for the helmet-chin PET – A simulation study," Nuclear Instruments and Methods in Physics Research A 858, pp. 96–100 2017
Abdella M Ahmed, Hideaki Tashim, Taiga Yamaya, "Simulation study of a D-shape PET scanner for improved sensitivity and reduced cost in whole-body imaging," Phys. Med. Biol., Vol., 62, pp. 4107-4117 2017
Abdella M Ahmed, Hideaki Tashima, Eiji Yoshida, Fumihiko Nishikido, Taiga Yamaya, “Simulation study comparing the helmet-chin PET with a cylindrical PET of the same number of detectors,” Phys. Med. Biol., vol. 62, pp. 4541-4550 2017
Akram Mohammadi, Naoko Inadama, Eiji Yoshida, Fumihiko Nishikido, Keiji Shimizu, Taiga Yamaya, "Improvement of crystal identification performance for a four-layer DOI detector composed of crystals segmented by laser processing," Nuclear Inst. and Methods in Physics Research, A 866, pp. 29–35 2017
F. Nishikido, M. Fujiwara, H. Tashima, M. S. H. Akram, M. Suga, T. Obata, T. Yamaya, "Development of a full-ring "add-on PET" prototype: A head coil with DOI-PET detectors for integrated PET/MRI," Nuclear Instruments and Methods in Physics Research, A 863, pp. 55–61 2017
Eiji Yoshida, Hideaki Tashima, Tetsuya Shinaji, Keiji Shimizu, Hidekatsu Wakizaka, Akram Mohammadi, Fumihiko Nishikido, Taiga Yamaya, "Development of a whole-body dual ring OpenPET for in-beam PET," IEEE Transactions on Radiation and Plasma Medical Sciences, Vol. 1, No. 4, pp. 293-300 2017
A. Koyama,H. Miyoshi, K. Shimazoe, Y. Otaka, M. Nitta, F. Nishikido, T. Yamaya, H. Takahashi, "Radiation stability of an InGaZnO thin-film transistor in heavy ion radiotherapy," Biomed. Phys. Eng. Express, 3, 045009 2017
Md Shahadat Hossain Akram, Takayuki Obata, Mikio Suga, Fumihiko Nishikido, Eiji Yoshida, Kazuyuki Saito, Taiga Yamaya, “MRI compatibility study of an integrated PET/RF-coil prototype system at 3 T,” Journal of Magnetic Resonance 283, pp. 62-70 2017
T. Inaniwa, H. Tashima, N. Kanematsu, “Optimum size of a calibration phantom for x-ray CT to convert the Hounsfield units to stopping power ratios in charged particle therapy treatment planning,” Journal of Radiation Research, Vol. 59, No. 2, pp. 1–9 2017
# Review articles Year
山谷泰賀, "米国核医学会 SNMMI2018 参加記," 医学物理, 第 38 巻, 第 4 号, pp. 169–173, 2018. 2019
B. F. Hutton, T. Yamaya, L. R. Furenlid, “Dedicated Molecular Imaging Systems for Human Neurological Studies,” IEEE Transactions on Radiation and Plasma Medical Sciences, pp. 252-253, 2019. 2019
高橋美和子, 山谷泰賀, “次世代 PET 研究会 2019 を終えて,” Isotope News, No. 763, pp. 46-47, 2019. 2019
高橋美和子, 錦戸文彦, 山谷泰賀, "PET 装置の開発 その 1.シンチレータ結晶編," 臨床核医学, pp. 58-61, Vol. 52, No. 4, 2019. 2019
山谷泰賀, 高橋美和子, “次世代の頭部専用 PET 装置の開発,” 医学のあゆみ, Vol. 270, No. 9, pp. 699-706, 2019. 2019
高橋美和子, 錦戸文彦, 山谷泰賀, "PET 装置の開発 その 2.受光素子編," 臨床核医学, pp. 72-75, Vol. 52, No. 5, 2019. 2019
高橋美和子, 錦戸文彦, 山谷泰賀, "PET 装置の開発 その 3.電子回路編," 臨床核医学, pp. 91-93, Vol. 52, No. 6, 2019. 2019
山谷泰賀, "頭部専用PET装置の未来「医工学と放射線技術科学との融合:期待される新技術」," 日本放射線技術学会雑誌, Vol. 74, No. 2, pp. 182-184, 2018. 2018
錦戸文彦, 田島英朗, 吉田英治, 山谷泰賀, "核医学イメージングの最先端技術," 医学物理, 38 巻 1 号 pp. 10-18, 2018. 2018
山谷泰賀, "粒子線がん治療をその場で可視化できる新型PET装置の開発に成功," 科研費NEWS 2018年度, Vol. 2, p.17, 2018. 2018
田島英朗, "医療放射線技術学研究会「放射線を利用した医用イメージング装置における画像再構成の基礎と応用」開催報告," JAMIT News Letter, No. 29, pp. 11-12, 2018. 2018
山谷泰賀(共同執筆), "生体計測分析技術・医療機器," 研究開発の俯瞰報告書 ライフサイエンス・臨床医学分野2017年, pp. 326-452 2017
山谷泰賀, "DOI検出器が切り拓く次世代のPET装置の研究開発," 放射線医学総合研究所創立60周年記念誌, pp. 16-17 2017
三輪建太,我妻慧,山尾天翔,上高祐人,松原佳亮,赤松剛,今林悦子,“アミロイドPETの定量評価に関する研究,” 日本放射線技術学会雑誌.Vol. 73, pp. 1165-1174 2017
# Book chapters Year
山谷泰賀(共同執筆者のひとり), "17.4 医用画像診断", 加速器ハンドブック, pp. 479-482, 2018. 2018
Akram Mohammadi, Sakae Kinase and Mitra Safavi-Naeini, "Overview of computational mouse models," Capter 3 of the book "Computational Anatomical Animal Models: Methodological developments and research applications," 2018, IOP Publishing, ISBN 978-0-7503-1344-5, pp. 3-1 to 3-27, https://iopscience.iop.org/book/978-0-7503-1344-5 2018
Sakae Kinase, Akram Mohammadi and José-María Gómez-Ros, "Overview of computational frog models," Capture 5 of the book "Computational Anatomical Animal Models: Methodological developments and research applications," 2018, IOP Publishing, ISBN 978-0-7503-1344-5, pp. 5-1 to 5-9, https://iopscience.iop.org/book/978-0-7503-1344-5 2018
Taiga Yamaya, Hideaki Tashima, "OpenPET enabling PET imaging during radiotherapy," Book capter in Personalized Pathway-Activated Systems Imaging in Oncology: Principal and Instrumentation, Springer, pp. 55-84, 2017. 2017
山谷泰賀, "世界初の開放型PET装置の研究開発", 科学立国日本を築くpart II 次代を拓く気鋭の研究者たち, pp. 202-210, 2017 (日刊工業新聞社) 2017
# Press releases and news articles Year
“Running (simulated) rings around cancer,” ANSTO online news https://www.ansto.gov.au/news/running-simulated-rings-around-cancer 2019
“Optical imaging characterizes radioactive ion beams,” captured by physicsworld, 2019/6/27. https://physicsworld.com/a/optical-imaging-characterizes-radioactive-ion-beams/ 2019
“2019 SNMMI Highlights Lecture: Neurosciences”記事にてヘルメットPETが紹介される, Henryk Barthel, THE JOURNAL OF NUCLEAR MEDICINE, Vol. 60, No. 9, 14N, 2019. 2019
萩生田光一文部科学大臣が QST を視察され、ヘルメット型 PET 試作機をご覧になりました。(2019/12/16) https://www.qst.go.jp/soshiki/4/36499.html 2019
竹本直一内閣府特命担当大臣が QST を視察され、ヘルメット型 PET 試作機をご覧になりました。(2019/12/18) https://www.qst.go.jp/soshiki/4/36601.html 2019
“Washout model enhances particle range verification”appeared in MedicalPhysicsWeb http://medicalphysicsweb.org/cws/article/research/71337, 2018/4/2. 2018
"A Better PET" appeared in Proto Magagine (Massachusetts General Hospital), 2018/6/7 http://protomag.com/articles/better-pet 2018
テレビ「ガリレオX」にて、頭部PET装置紹介, 放送日 2018年6月24日(日) 昼11:30-12:00 BSフジ 2018
千葉大学と量子科学技術研究開発機構との包括的連携協力に関する協定書の締結について, プレスリリース, 2017/2/2 http://www.qst.go.jp/information/itemid034-001721.html (翌日の千葉日報、日刊工業、日経産業に展示したOpenPET試作機とともに「がん治療技術 確立へ」などのヘッドラインで紹介) 2017
"画像見てがん除去 量研機構が取りこぼし防ぐシステム," 日刊工業新聞1面, 2017/3/21. 2017
放射線医学総合研究所の研究員が平成29年度文部科学大臣表彰科学技術賞を受賞しました, ニュースリリース, 2017/4/19 http://www.qst.go.jp/information/itemid047-002154.html 2017
“第113回日本医学物理学会学術大会のCyPos大会長賞と英語プレゼンテーション賞を受賞しました,” ニュースリリース, 2017/5/16 http://www.nirs.qst.go.jp/information/news_prize/2017/0516.html 2017
“乳房専用PET装置「Elmammo」の研究・開発で「産学官連携功労者表彰 厚生労働大臣賞」を受賞”ニュースリリース, 2017/8/21 http://www.qst.go.jp/information/itemid034-002617.html 2017
# Awards Year
Han Gyu Kang, “韓国副首相・教育部長官賞を受賞しました,” 2019/3/20. https://www.qst.go.jp/site/qms/22933.html 2019
Hideaki Tashima, Eiji Yoshida, Yusuke Okumura, Mikio Suga, Naoki Kawachi, Kei Kamada, Katia Parodi, Taiga Yamaya, 第 117 回日本医学物理学会学術大会, President's Award Silver 受賞, 2019. ("Whole Gamma Imaging: Demonstration of the β+-γ Coincidence") https://www.qst.go.jp/site/qms/24218.html 2019
赤松剛, “心臓用高感度 PET 装置の実現に向けた近接型検出器配置の基礎的検討,” 第 29 回日本心臓核医学会総会・学術大会 第 8 回学会賞技術部門賞受賞, 2019/7/13. https://www.qst.go.jp/site/qms/28969.html 2019
三好悠太, 栗田圭輔, 長尾悠人, 山口充孝, 鈴井伸郎, 尹永根, 石井里美, 河地有木, 日高功太, 吉田英治, 田久創大, 田島英朗, 山谷泰賀, 日本土壌肥料学会 2019 年度静岡大会ポスター賞受賞, 2019. ("イチゴの種子は果実への炭素転流を駆動する") 2019
Go Akamatsu, Han Gyu Kang, Sodai Takyu, 2019 IEEE NSS-MIC Trainee Grant, 500.00 GBP/each person 2019
Taiga Yamaya, WFNMB2018 Best Poster Award Physics, 2018/4/23. (Taiga Yamaya, Eiji Yoshida, Hideaki Tashima, Go Akamatsu, Yuma Iwao, Hidekatsu Wakizaka, Takamasa Maeda, Yuhei Takado, Chie Seki, Makoto Higuchi, Tetsuya Suhara, Taichi Yamashita, “Imaging performance evaluation of a “helmet-neck” brain PET prototype,” 12th Congress of the World Federation of Nuclear Medicine and Biology (WFNMB), 2018) http://www.nirs.qst.go.jp/information/news_prize/2018/0511.html 2018
赤松剛, ほか, 第115回日本医学物理学会学術大会大会長賞, 2018/4/15 (Go Akamatsu, Sodai Takyu, Eiji Yoshida, Munetaka Nitta, Yuma Iwao, Akram Mohammadi, Hideaki Tashima, Taiga Yamaya, "Intrinsic performance evaluation of a new TOF-PET detector module with 256-ch 3-mm-pitch MPPC array") http://www.jsmp.org/conf/115/e_presentation.html http://www.nirs.qst.go.jp/information/news_prize/2018/0426.html 2018
田島英朗, 第115回日本医学物理学会学術大会英語プレゼンテーション賞, 2018/4/15 http://www.nirs.qst.go.jp/information/news_prize/2018/0605.html 2018
Han Gyu Kang, 2018 IEEE NSS-MIC Trainee Grant 2018
Yusuke Okumura, 2018 IEEE NSS-MIC Trainee Grant 2018
Sodai Takyu, 2018 IEEE NSS-MIC Trainee Grant 2018
Hideaki Tashima, poster award at the 5th NIRS-SNU Workshop on Nuclear Medicine Imaging Science and Technology. 2018
山谷泰賀, 吉田英治, 田島英朗, "開放型PET装置の発明と粒子線がん治療可視化法の研究," 平成29年度科学技術分野の文部科学大臣表彰科学技術賞(研究部門)受賞 (2017/4/19). Taiga Yamaya, Eiji Yoshida, Hideaki Tashima, “Invention of an open-type PET instrumentation and research on visualization of particle therapy,” Awarded the Science and Technology Prize by the Minister of Education, Culture, Sports, Science and Technology, April 19, 2017. http://www.mext.go.jp/b_menu/houdou/29/04/1384228.htm http://www.qst.go.jp/information/itemid047-002154.html 2017
山谷泰賀, 中本裕士, 北村圭司, “乳房専用PET装置「Elmammo」の開発に係る産学官連携,” 第15回産学官連携功労者表彰 厚生労働大臣賞 受賞 (2017/9/1). Taiga Yamaya, Yuji Nakamoto, Keishi Kitamura, “Industry-academia-government collaboration for the development of a breast dedicated PET, Elmammo,” Recognized as a Person of Collaboration Merits by the Minister of Health, Labour and Welfare, September 1, 2017. http://www8.cao.go.jp/cstp/sangakukan/index2.html http://www.qst.go.jp/information/itemid034-002617.html 2017
錦戸文彦, "Development of second add‒on PET/MRI prototype: Evaluation of PET imaging performance," O‒043, 第113回日本医学物理学会学術大会 CyPos大会長賞 Fumihiko Nishikido, the CyPos General Chair Award by the 113th Scientific Meeting of the Japan Society of Medical Physics 2017
田島英朗, "Development of a small prototype system toward real‒time OpenPET image‒guided surgery," O‒54, 第113回日本医学物理学会学術大会 英語プレゼンテーション賞 Hideaki Tashima, the English Presentation Award by the 113th Scientific Meeting of the Japan Society of Medical Physics 2017
山谷泰賀, "Whole gamma imaging concept: feasibility study of triple‒gamma imaging," O‒38, 第113回日本医学物理学会学術大会 英語プレゼンテーション賞 Taiga Yamaya, the English Presentation Award by the 113th Scientific Meeting of the Japan Society of Medical Physics http://www.jsmp.org/conf/113/e_presentation.html http://www.nirs.qst.go.jp/information/news_prize/2017/0516.html 2017
Md Shahadat Hossain Akram, Awarded to “ISMRM Summa Cum Laude Merit Award” for his presentation “Development and performance evaluation of the second prototype of a RF-coil integrated PET insert for existing 3T MRI systems,” (Given to Trainee Members whose abstracts score in the top 5% within a major subject review category) http://www.nirs.qst.go.jp/information/news_prize/2017/0602.html 2017
Md Shahadat Hossain Akram, IEEE NSS-MIC 2017 Trainee Grant ($500). 2017
Paper listed in “PMB Highlights in 2016” http://iopscience.iop.org/journal/0031-9155/page/Highlights_of_2016 Hideaki Tashima, …, Taiga Yamaya, "Development of a small single-ring OpenPET prototype with a novel transformable architecture," Phys. Med. Biol., Vol. 61, pp. 1795-1809, 2016 2017