Mood Disorders
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What are Mood Disorders?

Mood Disorders is a mental disorder that has disturbance in mood oremotion as a main symptom,and it causes depressive episodes (seebelow). Bipolar Disorder is characterized by the repetition of depressive and manic episodes.
Mood Disorders (Depressive episodes)

Mental symptoms
- Depressed mood: the loss of interest and pleasure in nearly all activities
- Suppressed psychomotor: decreased energy


Physical symptoms
- Decreased appetite and weight loss
- Sleep disturbance (especially early awakening)
- Lowered sexual desire
- Other physical changes (pain, constipation,dry mouth)

Mood Disorders (Manic episodes)

Mental symptoms
- Elevated, expansive, or irritated mood, distractibility
- Increased involvement in goal-directed activities or psychomotor agitation, and excessive involvement in pleasurable activities with a high potential for painful consequences.


Physical symptoms
- Weight loss
- Decreased need for sleep
- High sexual desire [DSM-R IV]

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It is known that medications that inhibit reuptake of serotoninneurotransmitter) to neurons (selective serotonin reuptakeinhibitor, SSRI) are effective fortreatment of Mood Disorders.

Now researchers pay greatattention to this abnormality inthe region of neurotransmission through reuptake (serotonin transporter) as a cause Of Mood Disorders.


In our institute, we measured the quantityof serotonin transporters in patients with Major Depressive Disorder and Bipolar Disorder and control subjects by PET using [11C](+)MCN5652.

This ligand has a selective and high affinity in comparison to other ligands so far used, and it enables in vivo measurement.

The slides show 90-minute summation images. It can be seen that there is a high accumulation of the ligand in thalamus, striatum and midbrain.

Serotonin transporters play an important role for many antidepressive medications, and changes in Mood Disorders are assumed to take place as a result.

We examined serotonin transporter binding in thalamus with PET using [11C](+)McN5652 and found that the binding was increased in Mood Disorders.

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