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Imaging Physiology Team / Biophysics Program

Introduction

The Imaging Physiology Team will develop the methods for quantitative analyses of in vivo imaging obtained from PET, MRI, and two-photon microscopy. Using these techniques, we will measure physiological parameters in vivo as a basis of diagnosis and treatment.


Team Leader
Yasuhisa Fujibayashi

Research Introduction

1. Development of quantification methods for PET data

To obtain physiological parameters from PET, we develop quantification methods for PET data and evaluate accuracy of these methods.


PET scanner (Shimadzu Corporation)

Development of a new graphical plot analysis for imaging the function of dopamine transporters
In a PET dynamic study with a dopamine transporter ligand [11C]PE2I, a new graphical plot analysis (left) easily provides not only the total distribution volume (VT) image (right), but also the nondisplaceable distribution volume (VND) and binding potential (BPND) those are difficult to estimate simultaneously by the conventional graphical methods.

2. Investigation of pathophysiology by combination of PET and MRI

We investigate to obtain integrated pathophysiological information from combination of PET and MRI analyses.

[MRI scanner]
MRI is a medical imaging technique to visualize the detailed structure in body using strong magnets. The high-resolution image can help to improve of accuracy of PET and to develop the new medical imaging technique.


3T MRI scanner (SIEMENS)

MR images and PET images
Diffusion MRI can detect the signal related to water diffusion in biological tissue. It was applied to the visualization of fiber tract such as white matter in brain. The water diffusion reflects the cell-level structure in biological tissue. The combination of diffusion MRI and PET will produce new useful markers for diagnosis and pathological analysis.

3. In vivo microimaging by two-photon laser scanning microscopy etc.

We develop microimaging system to observe cell and vessels in vivo, and investigate pathophysiological mechanisms as a basis of evaluation of pathophysiology by PET and MRI.


Two-photon laser scanning microscopy

Two-photon in vivo microimaging of microvessels (left) and astrocytes (right) in mice.

Members

Yasuhisa Fujibayashi
Team Leader
Yoko Ikoma
Assistant Director
Chie Seki , Yuhei Takado , Hiroyuki Takuwa , Asuka Nishino
Researcher
Jeffrey Kershaw
Technical Staff
Hiromi Sano
Clinical Radiologist
Iwao Kanno, Kazuto Masamoto
Visiting Collaborative Researcher
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